Names & Taxonomy

Uniprot ID:
Q02641
Entry Name:
CACB1_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)
Gene Names:
CACNB1 CACNLB1
Gene Names Primary:
CACNB1
Organism:
Homo sapiens (Human)

Structure

Length:
598
Sequence:
MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYPSSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGTPPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Function

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Cross Reference Drug Bank:
DB04855 DB00898 DB00308 DB00653 DB00393 DB00421 DB00661
Gene Ontology Go:
plasma membrane
sarcolemma
voltage-gated calcium channel complex
high voltage-gated calcium channel activity
voltage-gated calcium channel activity
axon guidance
cardiac conduction
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
Gene Ontology Biological Process:
axon guidance
cardiac conduction
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
transport
Gene Ontology Molecular Function:
high voltage-gated calcium channel activity
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
plasma membrane
sarcolemma
voltage-gated calcium channel complex
Keywords:
Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell membrane
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Transport
Voltage-gated channel

Publication

PubMed ID:
1385409 1309651 7916667 8905728 10624822 14702039 15489334 8395940 8107964 16959974