Names & Taxonomy

Uniprot ID:
Q02241
Entry Name:
KIF23_HUMAN
Status:
reviewed
Protein Names:
Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1)
Gene Names:
KIF23 KNSL5 MKLP1
Gene Names Primary:
KIF23
Organism:
Homo sapiens (Human)

Structure

Length:
960
Sequence:
MKSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGYRLNRNGDYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTHTMTGSPGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMPNPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFDPIKPKPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSRSHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREAGNINQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDYEENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPLPSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKENHMQGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKLQRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLKQLKAIVTEPKTEKPERPSRERDREKVTQRSVSPSPVPLSSNYIAQISNGQQLMSQPQLHRRSNSCSSISVASCISEWEQKIPTYNTPLKVTSIARRRQQEPGQSKTCIVSDRRRGMYWTEGREVVPTFRNEIEIEEDHCGRLLFQPDQNAPPIRLRHRRSRSAGDRWVDHKPASNMQTETVMQPHVPHAITVSVANEKALAKCEKYMLTHQELASDGEIETKLIKGDIYKTRGGGQSVQFTDIETLKQESPNGSRKRRSSTVAPAQPDGAESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.

Function

Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro.
Gene Ontology Go:
centralspindlin complex
centrosome
cytosol
focal adhesion
intercellular bridge
kinesin complex
microtubule
midbody
mitotic spindle
nucleoplasm
nucleus
spindle
ATP binding
ATPase activity
microtubule binding
microtubule motor activity
actomyosin contractile ring assembly
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cytokinesis
microtubule-based movement
mitotic cell cycle
mitotic cytokinesis
mitotic spindle elongation
mitotic spindle midzone assembly
plus-end-directed vesicle transport along microtubule
positive regulation of cytokinesis
Gene Ontology Biological Process:
actomyosin contractile ring assembly
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cytokinesis
microtubule-based movement
mitotic cell cycle
mitotic cytokinesis
mitotic spindle elongation
mitotic spindle midzone assembly
plus-end-directed vesicle transport along microtubule
positive regulation of cytokinesis
Gene Ontology Molecular Function:
ATPase activity
ATP binding
microtubule binding
microtubule motor activity
Gene Ontology Cellular Component:
centralspindlin complex
centrosome
cytosol
focal adhesion
intercellular bridge
kinesin complex
microtubule
midbody
mitotic spindle
nucleoplasm
nucleus
spindle
Keywords:
3D-structure
ATP-binding
Alternative splicing
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Isopeptide bond
Microtubule
Mitosis
Motor protein
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation
Interacts With:
P62330; P62331; Q9NR09; Q9H0H5; P63104

Publication

PubMed ID:
1406973 14702039 16572171 15489334 11782313 15297875 15197175 16103226 17081983 16236794 16964243 18329369 18220336 18669648 19413330 19468300 19690332 20068231 21269460 21406692 25772364 25755297 22522702