Names & Taxonomy

Uniprot ID:
Q01814
Entry Name:
AT2B2_HUMAN
Status:
reviewed
Protein Names:
Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
Gene Names:
ATP2B2 PMCA2
Gene Names Primary:
ATP2B2
Organism:
Homo sapiens (Human)

Structure

Length:
1243
Sequence:
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse

Function

Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic Activity:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
Active Site:
ACT_SITE 499 499 4-aspartylphosphate intermediate.
Gene Ontology Go:
apical plasma membrane
cell junction
cilium
cytoplasm
endoplasmic reticulum
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
neuronal cell body
plasma membrane
synapse
ATP binding
calcium ion binding
calcium-dependent ATPase activity
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
PDZ domain binding
protein C-terminus binding
auditory receptor cell stereocilium organization
blood coagulation
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
ion transmembrane transport
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
neuron differentiation
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cardiac conduction
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
sensory perception of sound
serotonin metabolic process
synapse organization
transmembrane transport
transport
Gene Ontology Biological Process:
auditory receptor cell stereocilium organization
blood coagulation
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
ion transmembrane transport
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
neuron differentiation
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cardiac conduction
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
sensory perception of sound
serotonin metabolic process
synapse organization
transmembrane transport
transport
Gene Ontology Molecular Function:
ATP binding
calcium-dependent ATPase activity
calcium ion binding
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
PDZ domain binding
protein C-terminus binding
Gene Ontology Cellular Component:
apical plasma membrane
cell junction
cilium
cytoplasm
endoplasmic reticulum
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
neuronal cell body
plasma membrane
synapse
Keywords:
ATP-binding
Alternative splicing
Calcium
Calcium transport
Calmodulin-binding
Cell junction
Cell membrane
Complete proteome
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Synapse
Transmembrane
Transmembrane helix
Transport
Interacts With:
P01258; Q63622; Q8SQG9

Publication

PubMed ID:
1427863 8428366 1313367 16641997 8245032 12763866 18669648 24275569