Names & Taxonomy
- Uniprot ID:
- Q01814
- Entry Name:
- AT2B2_HUMAN
- Status:
- reviewed
- Protein Names:
- Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)
- Gene Names:
- ATP2B2 PMCA2
- Gene Names Primary:
- ATP2B2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1243
- Sequence:
- MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Active Site:
- ACT_SITE 499 499 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- apical plasma membrane
cell junction
cilium
cytoplasm
endoplasmic reticulum
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
neuronal cell body
plasma membrane
synapse
ATP binding
calcium ion binding
calcium-dependent ATPase activity
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
PDZ domain binding
protein C-terminus binding
auditory receptor cell stereocilium organization
blood coagulation
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
ion transmembrane transport
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
neuron differentiation
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cardiac conduction
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
sensory perception of sound
serotonin metabolic process
synapse organization
transmembrane transport
transport - Gene Ontology Biological Process:
- auditory receptor cell stereocilium organization
blood coagulation
calcium ion transmembrane transport
calcium ion transport
cardiac conduction
cerebellar granule cell differentiation
cerebellar Purkinje cell differentiation
cGMP metabolic process
cochlea development
detection of mechanical stimulus involved in sensory perception of sound
ion transmembrane transport
lactation
locomotion
locomotory behavior
neuromuscular process controlling balance
neuron differentiation
organelle organization
otolith mineralization
positive regulation of calcium ion transport
regulation of cardiac conduction
regulation of cell size
regulation of cytosolic calcium ion concentration
regulation of synaptic plasticity
sensory perception of sound
serotonin metabolic process
synapse organization
transmembrane transport
transport - Gene Ontology Molecular Function:
- ATP binding
calcium-dependent ATPase activity
calcium ion binding
calcium-transporting ATPase activity
calmodulin binding
metal ion binding
PDZ domain binding
protein C-terminus binding - Gene Ontology Cellular Component:
- apical plasma membrane
cell junction
cilium
cytoplasm
endoplasmic reticulum
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
neuronal cell body
plasma membrane
synapse - Keywords:
- ATP-binding
Alternative splicing
Calcium
Calcium transport
Calmodulin-binding
Cell junction
Cell membrane
Complete proteome
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Synapse
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P01258; Q63622; Q8SQG9