Names & Taxonomy
- Uniprot ID:
- Q01813
- Entry Name:
- PFKAP_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
- Gene Names:
- PFKP PFKF
- Gene Names Primary:
- PFKP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 784
- Sequence:
- MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
- Catalytic Activity:
- ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
- Active Site:
- ACT_SITE 175 175 Proton acceptor.
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
nucleus
6-phosphofructokinase activity
ATP binding
metal ion binding
protein complex binding
canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
mitophagy in response to mitochondrial depolarization
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
mitophagy in response to mitochondrial depolarization
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructokinase activity
ATP binding
metal ion binding
protein complex binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Glycolysis
Glycoprotein
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase