Names & Taxonomy

Uniprot ID:
Q01813
Entry Name:
PFKAP_HUMAN
Status:
reviewed
Protein Names:
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)
Gene Names:
PFKP PFKF
Gene Names Primary:
PFKP
Organism:
Homo sapiens (Human)

Structure

Length:
784
Sequence:
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Pathway:
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
Catalytic Activity:
ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation:
ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
Active Site:
ACT_SITE 175 175 Proton acceptor.
Gene Ontology Go:
cytosol
extracellular exosome
membrane
nucleus
6-phosphofructokinase activity
ATP binding
metal ion binding
protein complex binding
canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
mitophagy in response to mitochondrial depolarization
small molecule metabolic process
Gene Ontology Biological Process:
canonical glycolysis
carbohydrate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
mitophagy in response to mitochondrial depolarization
small molecule metabolic process
Gene Ontology Molecular Function:
6-phosphofructokinase activity
ATP binding
metal ion binding
protein complex binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
membrane
nucleus
Keywords:
3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Glycolysis
Glycoprotein
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

Publication

PubMed ID:
8117307 14702039 15164054 15489334 1834056 15592455 16964243 18691976 18669648 19413330 19690332 19608861 20068231 21269460 21406692