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Names & Taxonomy

Uniprot ID:: Q00987
Entry Name:: MDM2_HUMAN
Status:: reviewed
Protein Names:: E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (p53-binding protein Mdm2)
Gene Names:: MDM2
Gene Names Primary:: MDM2
Organism:: Homo sapiens (Human)

Structure

Length:: 491
Sequence:: MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

Function

Function:: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.
Gene Ontology Go:: cytoplasm
cytosol
endocytic vesicle membrane
nucleolus
nucleoplasm
nucleus
plasma membrane
protein complex
synapse
enzyme binding
identical protein binding
ligase activity
p53 binding
ubiquitin protein ligase activity
ubiquitin protein ligase binding
ubiquitin-protein transferase activity
zinc ion binding
atrial septum development
atrioventricular valve morphogenesis
blood vessel development
blood vessel remodeling
cardiac septum morphogenesis
cellular response to alkaloid
cellular response to antibiotic
cellular response to estrogen stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to peptide hormone stimulus
cellular response to UV-C
cellular response to vitamin B1
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
endocardial cushion morphogenesis
epidermal growth factor receptor signaling pathway
establishment of protein localization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
negative regulation of cell cycle arrest
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of protein processing
negative regulation of signal transduction by p53 class mediator
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neurotrophin TRK receptor signaling pathway
peptidyl-lysine modification
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of mitotic cell cycle
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein export from nucleus
protein complex assembly
protein destabilization
protein localization to nucleus
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of heart rate
regulation of protein catabolic process
response to antibiotic
response to carbohydrate
response to cocaine
response to drug
response to ether
response to iron ion
response to magnesium ion
response to morphine
synaptic transmission
traversing start control point of mitotic cell cycle
ventricular septum development
viral process
Gene Ontology Biological Process:: atrial septum development
atrioventricular valve morphogenesis
blood vessel development
blood vessel remodeling
cardiac septum morphogenesis
cellular response to alkaloid
cellular response to antibiotic
cellular response to estrogen stimulus
cellular response to hydrogen peroxide
cellular response to hypoxia
cellular response to peptide hormone stimulus
cellular response to UV-C
cellular response to vitamin B1
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
endocardial cushion morphogenesis
epidermal growth factor receptor signaling pathway
establishment of protein localization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
negative regulation of cell cycle arrest
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of protein processing
negative regulation of signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neurotrophin TRK receptor signaling pathway
peptidyl-lysine modification
phosphatidylinositol-mediated signaling
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of mitotic cell cycle
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein export from nucleus
protein complex assembly
protein destabilization
protein localization to nucleus
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of heart rate
regulation of protein catabolic process
response to antibiotic
response to carbohydrate
response to cocaine
response to drug
response to ether
response to iron ion
response to magnesium ion
response to morphine
synaptic transmission
traversing start control point of mitotic cell cycle
ventricular septum development
viral process
Gene Ontology Molecular Function:: enzyme binding
identical protein binding
ligase activity
p53 binding
ubiquitin protein ligase activity
ubiquitin protein ligase binding
ubiquitin-protein transferase activity
zinc ion binding
Gene Ontology Cellular Component:: cytoplasm
cytosol
endocytic vesicle membrane
nucleolus
nucleoplasm
nucleus
plasma membrane
protein complex
synapse
Keywords:: 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Host-virus interaction
Ligase
Metal-binding
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger
Interacts With:: Itself; P25098; P31749; P10275; Q9Y297; P42574; Q8N726; P48729; P48729-2; P48730; Q06486; P49674; Q13616; Q9UER7; P78352; P68104; P03372; P15311; Q9UKB1; Q00688; Q62446; Q9BVP2; Q9NVN8; Q5T7V8; P61978; P08069; Q8N9B5; P05412; P17535; O15151; P19338; P06748; Q61937; Q15466; Q96FW1; P53350; P29590; P29590-5; O15297; Q13362; P25788; P61289; Q9NS23; P06400; P62913; P62829; P46777; P42677; Q71UM5; P23396; P62081; Q8N488; Q92736; P23297; P29034; P26447; P06703; P04271; Q01105; P04637; P0CG48; O75604; Q93009; Q2HR73

Names & Taxonomy

Structure

Subcellular location

Function

Publication