Names & Taxonomy
- Uniprot ID:
- Q00536
- Entry Name:
- CDK16_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
- Gene Names:
- CDK16 PCTAIRE1 PCTK1
- Gene Names Primary:
- CDK16
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 496
- Sequence:
- MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome
Function
- Function:
- Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Active Site:
- ACT_SITE 286 286 Proton acceptor.
- Gene Ontology Go:
- cell junction
cytoplasm
extrinsic component of cytoplasmic side of plasma membrane
microtubule cytoskeleton
neuron projection
plasma membrane
synaptic vesicle
ATP binding
cyclin-dependent protein serine/threonine kinase activity
protein serine/threonine kinase activity
exocytosis
growth hormone secretion
neuron projection development
protein phosphorylation
regulation of insulin secretion involved in cellular response to glucose stimulus
spermatogenesis - Gene Ontology Biological Process:
- exocytosis
growth hormone secretion
neuron projection development
protein phosphorylation
regulation of insulin secretion involved in cellular response to glucose stimulus
spermatogenesis - Gene Ontology Molecular Function:
- ATP binding
cyclin-dependent protein serine/threonine kinase activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cell junction
cytoplasm
extrinsic component of cytoplasmic side of plasma membrane
microtubule cytoskeleton
neuron projection
plasma membrane
synaptic vesicle - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Differentiation
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Spermatogenesis
Synapse
Synaptosome
Transferase - Interacts With:
- Q92624; Q8ND76-1; Q8N7R7; Q15436; O43829