Names & Taxonomy
- Uniprot ID:
- P98194
- Entry Name:
- AT2C1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 3.6.3.8) (ATP-dependent Ca(2+) pump PMR1)
- Gene Names:
- ATP2C1 KIAA1347 PMR1L HUSSY-28
- Gene Names Orf:
- HUSSY-28
- Gene Names Primary:
- ATP2C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 919
- Sequence:
- MKVARFQKIPNGENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVERSREKIQKHVSSTSSSFLEV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
- Catalytic Activity:
- ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
- Active Site:
- ACT_SITE 350 350 4-aspartylphosphate intermediate.
- Cross Reference Drug Bank:
- DB01189 DB00228 DB01159 DB00753 DB01028 DB01236
- Gene Ontology Go:
- Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
membrane
trans-Golgi network
ATP binding
calcium ion binding
calcium-transporting ATPase activity
manganese ion binding
manganese-transporting ATPase activity
metal ion binding
signal transducer activity
actin cytoskeleton reorganization
calcium ion transmembrane transport
calcium ion transport
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cellular calcium ion homeostasis
cellular manganese ion homeostasis
epidermis development
Golgi calcium ion homeostasis
Golgi calcium ion transport
ion transmembrane transport
manganese ion transmembrane transport
manganese ion transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
transmembrane transport - Gene Ontology Biological Process:
- actin cytoskeleton reorganization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
calcium ion transmembrane transport
calcium ion transport
cellular calcium ion homeostasis
cellular manganese ion homeostasis
epidermis development
Golgi calcium ion homeostasis
Golgi calcium ion transport
ion transmembrane transport
manganese ion transmembrane transport
manganese ion transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
signal transduction
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
calcium ion binding
calcium-transporting ATPase activity
manganese ion binding
manganese-transporting ATPase activity
metal ion binding
signal transducer activity - Gene Ontology Cellular Component:
- Golgi apparatus
Golgi membrane
integral component of membrane
integral component of plasma membrane
membrane
trans-Golgi network - Keywords:
- ATP-binding
Alternative splicing
Calcium
Calcium transport
Complete proteome
Disease mutation
Golgi apparatus
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport