Names & Taxonomy
- Uniprot ID:
- P78357
- Entry Name:
- CNTP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190)
- Gene Names:
- CNTNAP1 CASPR NRXN4
- Gene Names Primary:
- CNTNAP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1384
- Sequence:
- MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
myelin sheath
paranode region of axon
voltage-gated potassium channel complex
receptor activity
SH3 domain binding
SH3/SH2 adaptor activity
axon guidance
cell adhesion
cytoskeleton organization
neuromuscular process controlling balance
neuromuscular process controlling posture
neuron projection morphogenesis
neuronal action potential propagation
paranodal junction assembly
positive regulation of signal transduction
protein localization to paranode region of axon
signal transduction - Gene Ontology Biological Process:
- axon guidance
cell adhesion
cytoskeleton organization
neuromuscular process controlling balance
neuromuscular process controlling posture
neuronal action potential propagation
neuron projection morphogenesis
paranodal junction assembly
positive regulation of signal transduction
protein localization to paranode region of axon
signal transduction - Gene Ontology Molecular Function:
- receptor activity
SH3/SH2 adaptor activity
SH3 domain binding - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
myelin sheath
paranode region of axon
voltage-gated potassium channel complex - Keywords:
- Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P16333