Names & Taxonomy

Uniprot ID:
P78357
Entry Name:
CNTP1_HUMAN
Status:
reviewed
Protein Names:
Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (p190)
Gene Names:
CNTNAP1 CASPR NRXN4
Gene Names Primary:
CNTNAP1
Organism:
Homo sapiens (Human)

Structure

Length:
1384
Sequence:
MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
myelin sheath
paranode region of axon
voltage-gated potassium channel complex
receptor activity
SH3 domain binding
SH3/SH2 adaptor activity
axon guidance
cell adhesion
cytoskeleton organization
neuromuscular process controlling balance
neuromuscular process controlling posture
neuron projection morphogenesis
neuronal action potential propagation
paranodal junction assembly
positive regulation of signal transduction
protein localization to paranode region of axon
signal transduction
Gene Ontology Biological Process:
axon guidance
cell adhesion
cytoskeleton organization
neuromuscular process controlling balance
neuromuscular process controlling posture
neuronal action potential propagation
neuron projection morphogenesis
paranodal junction assembly
positive regulation of signal transduction
protein localization to paranode region of axon
signal transduction
Gene Ontology Molecular Function:
receptor activity
SH3/SH2 adaptor activity
SH3 domain binding
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
myelin sheath
paranode region of axon
voltage-gated potassium channel complex
Keywords:
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane
Transmembrane helix
Interacts With:
P16333

Publication

PubMed ID:
9118959 24319099