Names & Taxonomy
- Uniprot ID:
- P69905
- Entry Name:
- HBA_HUMAN
- Status:
- reviewed
- Protein Names:
- Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)
- Gene Names:
- HBA1; HBA2
- Gene Names Orf:
- ;
- Gene Names Primary:
- HBA1; HBA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 142
- Sequence:
- MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR
- Proteomes:
- UP000005640
Function
- Function:
- Involved in oxygen transport from the lung to the various peripheral tissues.
- Cross Reference Drug Bank:
- DB00893 DB00358
- Gene Ontology Go:
- blood microparticle
cytosol
cytosolic small ribosomal subunit
endocytic vesicle lumen
extracellular exosome
extracellular region
haptoglobin-hemoglobin complex
hemoglobin complex
membrane
heme binding
iron ion binding
oxygen binding
oxygen transporter activity
bicarbonate transport
cellular oxidant detoxification
hydrogen peroxide catabolic process
oxygen transport
positive regulation of cell death
protein heterooligomerization
receptor-mediated endocytosis
response to hydrogen peroxide
small molecule metabolic process - Gene Ontology Biological Process:
- bicarbonate transport
cellular oxidant detoxification
hydrogen peroxide catabolic process
oxygen transport
positive regulation of cell death
protein heterooligomerization
receptor-mediated endocytosis
response to hydrogen peroxide
small molecule metabolic process - Gene Ontology Molecular Function:
- heme binding
iron ion binding
oxygen binding
oxygen transporter activity - Gene Ontology Cellular Component:
- blood microparticle
cytosol
cytosolic small ribosomal subunit
endocytic vesicle lumen
extracellular exosome
extracellular region
haptoglobin-hemoglobin complex
hemoglobin complex
membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
Glycation
Glycoprotein
Heme
Hereditary hemolytic anemia
Iron
Metal-binding
Oxygen transport
Phosphoprotein
Polymorphism
Reference proteome
Transport - Interacts With:
- Q2TAC2; P68871; Q6A162
Publication
- PubMed ID:
- 7448866 6244294 6452630 6946451 11410421 11402454 16728641 11157797 15616553 15489334 13872627 13954546 14093912 12665801 1428951 7358733 19608861 21269460 24275569 25944712 1177322 7373648 1512262 9665850 8448109 5988206 5440849 5091982 5288820 5085669 4667378 5033650 4744335 4521212 4824923 1182166 849454 20980 902765 108887 486536 478975 7435503 7213661 7462179 7410435 7238857 7275660 7068434 7068437 6882779 6188720 6874376 6874377 6714429 6547117 6547932 6725558 3973024 3142772 2599879 2634665 2634669 2108715 2079432 1390940 1390944 1428941 8493987 8237999 8798486 5115619 9322075 8148419 6526652 10206681 2101836 2606724 2752146 9494044 4528583 1634363 6815131 5780195 3654264 4212045 1634355 8195005 7558876 7713747 8294199 1115799 7470621 9452028 1802882 7161109 478977 2833478 2079430 8745434 1618774 7786798 1634357 8294200 1686260 3754246 1428950 1511986 10569720 10569723 14576901 15495251 15921163