Names & Taxonomy
- Uniprot ID:
- P68366
- Entry Name:
- TBA4A_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin alpha-4A chain (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain)
- Gene Names:
- TUBA4A TUBA1
- Gene Names Primary:
- TUBA4A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 448
- Sequence:
- MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGKHVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLDRIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGIDSYEDEDEGEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Cross Reference Drug Bank:
- DB06772 DB01179 DB00541
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular region
microtubule
GTP binding
GTPase activity
structural constituent of cytoskeleton
'de novo' posttranslational protein folding
blood coagulation
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
platelet activation
platelet degranulation
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
blood coagulation
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
organelle organization
platelet activation
platelet degranulation
protein folding - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular region
microtubule - Keywords:
- Acetylation
Alternative splicing
Amyotrophic lateral sclerosis
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Microtubule
Neurodegeneration
Nitration
Nucleotide-binding
Phosphoprotein
Reference proteome - Interacts With:
- P30622