Names & Taxonomy
- Uniprot ID:
- P68363
- Entry Name:
- TBA1B_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain)
- Gene Names:
- TUBA1B
- Gene Names Primary:
- TUBA1B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 451
- Sequence:
- MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Gene Ontology Go:
- cytoplasmic microtubule
extracellular exosome
microtubule
myelin sheath
double-stranded RNA binding
GTP binding
GTPase activity
structural constituent of cytoskeleton
structural molecule activity
ubiquitin protein ligase binding
'de novo' posttranslational protein folding
cell division
cellular protein metabolic process
cellular response to interleukin-4
cytoskeleton-dependent intracellular transport
microtubule cytoskeleton organization
microtubule-based process
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cell division
cellular protein metabolic process
cellular response to interleukin-4
cytoskeleton-dependent intracellular transport
microtubule-based process
microtubule cytoskeleton organization
protein folding - Gene Ontology Molecular Function:
- double-stranded RNA binding
GTPase activity
GTP binding
structural constituent of cytoskeleton
structural molecule activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytoplasmic microtubule
extracellular exosome
microtubule
myelin sheath - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nitration
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation - Interacts With:
- Q6RW13; Q8AZK7; Q13509