Names & Taxonomy

Uniprot ID:
P68032
Entry Name:
ACTC_HUMAN
Status:
reviewed
Protein Names:
Actin, alpha cardiac muscle 1 (Alpha-cardiac actin)
Gene Names:
ACTC1 ACTC
Gene Names Primary:
ACTC1
Organism:
Homo sapiens (Human)

Structure

Length:
377
Sequence:
MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton.

Function

Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Gene Ontology Go:
actin filament
actomyosin, actin portion
blood microparticle
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
I band
lamellipodium
membrane
sarcomere
ATP binding
ATPase activity
myosin binding
actin filament-based movement
actin-myosin filament sliding
actomyosin structure organization
apoptotic process
cardiac muscle contraction
cardiac muscle tissue morphogenesis
cardiac myofibril assembly
heart contraction
mesenchyme migration
muscle filament sliding
negative regulation of apoptotic process
positive regulation of gene expression
response to drug
response to ethanol
skeletal muscle thin filament assembly
Gene Ontology Biological Process:
actin filament-based movement
actin-myosin filament sliding
actomyosin structure organization
apoptotic process
cardiac muscle contraction
cardiac muscle tissue morphogenesis
cardiac myofibril assembly
heart contraction
mesenchyme migration
muscle filament sliding
negative regulation of apoptotic process
positive regulation of gene expression
response to drug
response to ethanol
skeletal muscle thin filament assembly
Gene Ontology Molecular Function:
ATPase activity
ATP binding
myosin binding
Gene Ontology Cellular Component:
actin filament
actomyosin, actin portion
blood microparticle
cell body
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
I band
lamellipodium
membrane
sarcomere
Keywords:
ATP-binding
Atrial septal defect
Cardiomyopathy
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Isopeptide bond
Methylation
Muscle protein
Nucleotide-binding
Oxidation
Reference proteome

Publication

PubMed ID:
6310553 15489334 19015515 23673617 26228148 9563954 10330430 10966831 14729850 17947298 18403758