Names & Taxonomy
- Uniprot ID:
- P63316
- Entry Name:
- TNNC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Troponin C, slow skeletal and cardiac muscles (TN-C)
- Gene Names:
- TNNC1 TNNC
- Gene Names Primary:
- TNNC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 161
- Sequence:
- MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE
- Proteomes:
- UP000005640
Function
- Function:
- Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
- Cross Reference Drug Bank:
- DB01244 DB01375 DB01023 DB00922 DB00831
- Gene Ontology Go:
- actin cytoskeleton
cytosol
mitochondrion
nucleoplasm
troponin complex
actin filament binding
calcium ion binding
calcium-dependent protein binding
protein homodimerization activity
troponin I binding
troponin T binding
cardiac muscle contraction
diaphragm contraction
muscle filament sliding
regulation of ATPase activity
regulation of muscle contraction
regulation of muscle filament sliding speed
response to metal ion
transition between fast and slow fiber
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Biological Process:
- cardiac muscle contraction
diaphragm contraction
muscle filament sliding
regulation of ATPase activity
regulation of muscle contraction
regulation of muscle filament sliding speed
response to metal ion
transition between fast and slow fiber
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Molecular Function:
- actin filament binding
calcium-dependent protein binding
calcium ion binding
protein homodimerization activity
troponin I binding
troponin T binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cytosol
mitochondrion
nucleoplasm
troponin complex - Keywords:
- 3D-structure
Acetylation
Calcium
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Metal-binding
Muscle protein
Phosphoprotein
Polymorphism
Reference proteome
Repeat