Names & Taxonomy

Uniprot ID:
P63151
Entry Name:
2ABA_HUMAN
Status:
reviewed
Protein Names:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha)
Gene Names:
PPP2R2A
Gene Names Primary:
PPP2R2A
Organism:
Homo sapiens (Human)

Structure

Length:
447
Sequence:
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNNLYIFQDKVN
Proteomes:
UP000005640

Function

Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Gene Ontology Go:
cytosol
nucleoplasm
protein phosphatase type 2A complex
protein phosphatase type 2A regulator activity
protein serine/threonine phosphatase activity
G2/M transition of mitotic cell cycle
gene expression
mitotic cell cycle
mitotic nuclear envelope reassembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein dephosphorylation
regulation of protein phosphatase type 2A activity
response to morphine
Gene Ontology Biological Process:
G2/M transition of mitotic cell cycle
gene expression
mitotic cell cycle
mitotic nuclear envelope reassembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein dephosphorylation
regulation of protein phosphatase type 2A activity
response to morphine
Gene Ontology Molecular Function:
protein phosphatase type 2A regulator activity
protein serine/threonine phosphatase activity
Gene Ontology Cellular Component:
cytosol
nucleoplasm
protein phosphatase type 2A complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Reference proteome
Repeat
WD repeat
Interacts With:
P30153; P30154

Publication

PubMed ID:
1849734 14702039 16421571 15489334 17245430 19413330 21269460 22223895 24275569