Names & Taxonomy
- Uniprot ID:
- P63096
- Entry Name:
- GNAI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
- Gene Names:
- GNAI1
- Gene Names Primary:
- GNAI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935).
- Gene Ontology Go:
- centrosome
cytoplasm
extracellular exosome
heterotrimeric G-protein complex
lysosomal membrane
membrane raft
midbody
nucleus
plasma membrane
G-protein beta/gamma-subunit complex binding
G-protein coupled receptor binding
G-protein coupled serotonin receptor binding
GDP binding
GTP binding
GTPase activity
magnesium ion binding
signal transducer activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
cell cycle
cell division
cellular response to forskolin
G-protein coupled receptor signaling pathway
negative regulation of synaptic transmission
platelet activation
regulation of cAMP-mediated signaling
response to peptide hormone
synaptic transmission - Gene Ontology Biological Process:
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
blood coagulation
cell cycle
cell division
cellular response to forskolin
G-protein coupled receptor signaling pathway
negative regulation of synaptic transmission
platelet activation
regulation of cAMP-mediated signaling
response to peptide hormone
synaptic transmission - Gene Ontology Molecular Function:
- GDP binding
G-protein beta/gamma-subunit complex binding
G-protein coupled receptor binding
G-protein coupled serotonin receptor binding
GTPase activity
GTP binding
magnesium ion binding
signal transducer activity - Gene Ontology Cellular Component:
- centrosome
cytoplasm
extracellular exosome
heterotrimeric G-protein complex
lysosomal membrane
membrane raft
midbody
nucleus
plasma membrane - Keywords:
- 3D-structure
ADP-ribosylation
Alternative splicing
Cell cycle
Cell division
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Lipoprotein
Magnesium
Membrane
Metal-binding
Myristate
Nucleotide-binding
Nucleus
Palmitate
Reference proteome
Transducer - Interacts With:
- P81274; Q9Y4H4; Q14980; Q9UGC6