Names & Taxonomy
- Uniprot ID:
- P63092
- Entry Name:
- GNAS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
- Gene Names:
- GNAS GNAS1 GSP
- Gene Names Primary:
- GNAS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 394
- Sequence:
- MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
heterotrimeric G-protein complex
intrinsic component of membrane
membrane
plasma membrane
trans-Golgi network membrane
adenylate cyclase activity
GTP binding
GTPase activity
metal ion binding
signal transducer activity
activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
blood coagulation
bone development
cAMP biosynthetic process
cellular response to catecholamine stimulus
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cognition
developmental growth
energy reserve metabolic process
hair follicle placode formation
intracellular transport
platelet aggregation
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
regulation of insulin secretion
renal water homeostasis
sensory perception of smell
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
blood coagulation
bone development
cAMP biosynthetic process
cellular response to catecholamine stimulus
cellular response to glucagon stimulus
cellular response to prostaglandin E stimulus
cognition
developmental growth
energy reserve metabolic process
hair follicle placode formation
intracellular transport
platelet aggregation
positive regulation of cAMP biosynthetic process
positive regulation of cAMP-mediated signaling
positive regulation of GTPase activity
regulation of insulin secretion
renal water homeostasis
sensory perception of smell
small molecule metabolic process
transmembrane transport
water transport - Gene Ontology Molecular Function:
- adenylate cyclase activity
GTPase activity
GTP binding
metal ion binding
signal transducer activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
heterotrimeric G-protein complex
intrinsic component of membrane
membrane
plasma membrane
trans-Golgi network membrane - Keywords:
- ADP-ribosylation
Alternative splicing
Cell membrane
Complete proteome
Cushing syndrome
Direct protein sequencing
Disease mutation
GTP-binding
Isopeptide bond
Lipoprotein
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Obesity
Palmitate
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Transducer
Ubl conjugation - Interacts With:
- O89053; P42866
Publication
- PubMed ID:
- 3093273 3131741 3127824 11780052 15489334 3024154 15242332 12391161 17110384 20852621 20068231 21269460 21044946 24275569 26206488 25944712 8388883 1594625 1944469 2549426 7523385 8072545 7751320 7737262 8766942 8702665 9267696 9328353 9159128 9727013 10571700 10200251 11067869 11294659 11029463 11450852 11600516 11788646 11926205 12858292 12624854 12656668 12727968 14561710 14723729 15800843 15817905 15592469 21488135