Names & Taxonomy
- Uniprot ID:
- P62714
- Entry Name:
- PP2AB_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
- Gene Names:
- PPP2CB
- Gene Names Primary:
- PPP2CB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 309
- Sequence:
- MDDKAFTKELDQWVEQLNECKQLNENQVRTLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
- Catalytic Activity:
- -serine/threonine phosphate + H(2)O = -serine/threonine + phosphate.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Active Site:
- ACT_SITE 118 118 Proton donor.
- Cross Reference Drug Bank:
- DB00163
- Gene Ontology Go:
- chromosome, centromeric region
cytosol
extracellular exosome
nucleus
protein phosphatase type 2A complex
spindle pole
metal ion binding
phosphoprotein phosphatase activity
apoptotic mitochondrial changes
fibroblast growth factor receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
protein dephosphorylation
regulation of gene expression
response to antibiotic
response to endoplasmic reticulum stress
response to hydrogen peroxide - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
fibroblast growth factor receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
protein dephosphorylation
regulation of gene expression
response to antibiotic
response to endoplasmic reticulum stress
response to hydrogen peroxide - Gene Ontology Molecular Function:
- metal ion binding
phosphoprotein phosphatase activity - Gene Ontology Cellular Component:
- chromosome, centromeric region
cytosol
extracellular exosome
nucleus
protein phosphatase type 2A complex
spindle pole - Keywords:
- Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Hydrolase
Manganese
Metal-binding
Methylation
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Ubl conjugation - Interacts With:
- Q13642-2; Q9Y2T1; P78318