Names & Taxonomy
- Uniprot ID:
- P62508
- Entry Name:
- ERR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
- Gene Names:
- ESRRG ERR3 ERRG2 KIAA0832 NR3B3
- Gene Names Primary:
- ESRRG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 458
- Sequence:
- MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
- Cross Reference Drug Bank:
- DB02659 DB00255
- Gene Ontology Go:
- nucleoplasm
AF-2 domain binding
retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding
gene expression
positive regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- gene expression
positive regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- AF-2 domain binding
retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid binding
steroid hormone receptor activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
- Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- G2XKQ0; Q05D60; Q9BVG8; A4D127; P51843; Q12769; Q9UBK2; A0MZ66