Names & Taxonomy
- Uniprot ID:
- P61457
- Entry Name:
- PHS_HUMAN
- Status:
- reviewed
- Protein Names:
- Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)
- Gene Names:
- PCBD1 DCOH PCBD
- Gene Names Primary:
- PCBD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 104
- Sequence:
- MAGKAHRLSAEERDQLLPNLRAVGWNELEGRDAIFKQFHFKDFNRAFGFMTRVALQAEKLDHHPEWFNVYNKVHITLSTHECAGLSERDINLASFIEQVAVSMT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Cytoplasmic and/or nuclear.
Function
- Function:
- Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity.
- Catalytic Activity:
- (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm
4-alpha-hydroxytetrahydrobiopterin dehydratase activity
identical protein binding
phenylalanine 4-monooxygenase activity
transcription coactivator activity
cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
positive regulation of transcription, DNA-templated
protein heterooligomerization
protein homotetramerization
regulation of protein homodimerization activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
transcription, DNA-templated - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
L-phenylalanine catabolic process
positive regulation of transcription, DNA-templated
protein heterooligomerization
protein homotetramerization
regulation of protein homodimerization activity
small molecule metabolic process
tetrahydrobiopterin biosynthetic process
transcription, DNA-templated - Gene Ontology Molecular Function:
- 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
identical protein binding
phenylalanine 4-monooxygenase activity
transcription coactivator activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
nucleoplasm - Keywords:
- Acetylation
Activator
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Lyase
Nucleus
Reference proteome
Tetrahydrobiopterin biosynthesis
Transcription
Transcription regulation - Interacts With:
- Itself; Q9UKV3; P05067; P51116; Q8TBB1; Q07654