Names & Taxonomy
- Uniprot ID:
- P60568
- Entry Name:
- IL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
- Gene Names:
- IL2
- Gene Names Primary:
- IL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 153
- Sequence:
- MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
- Cross Reference Drug Bank:
- DB05676 DB00852
- Gene Ontology Go:
- cytosol
extracellular region
extracellular space
carbohydrate binding
cytokine activity
glycosphingolipid binding
growth factor activity
interleukin-2 receptor binding
kinase activator activity
activation of MAPKK activity
adaptive immune response
axon guidance
cell adhesion
cell-cell signaling
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
negative regulation of B cell apoptotic process
negative regulation of heart contraction
negative regulation of inflammatory response
negative regulation of lymphocyte proliferation
negative regulation of protein phosphorylation
neurotrophin TRK receptor signaling pathway
positive regulation of activated T cell proliferation
positive regulation of B cell proliferation
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of dendritic spine development
positive regulation of immunoglobulin secretion
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of isotype switching to IgG isotypes
positive regulation of regulatory T cell differentiation
positive regulation of tissue remodeling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tyrosine phosphorylation of Stat5 protein
protein kinase C-activating G-protein coupled receptor signaling pathway
Ras protein signal transduction
regulation of T cell homeostatic proliferation
response to ethanol
small GTPase mediated signal transduction
T cell differentiation
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
adaptive immune response
axon guidance
cell adhesion
cell-cell signaling
epidermal growth factor receptor signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
immune response
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
negative regulation of B cell apoptotic process
negative regulation of heart contraction
negative regulation of inflammatory response
negative regulation of lymphocyte proliferation
negative regulation of protein phosphorylation
neurotrophin TRK receptor signaling pathway
positive regulation of activated T cell proliferation
positive regulation of B cell proliferation
positive regulation of cell growth
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of dendritic spine development
positive regulation of immunoglobulin secretion
positive regulation of inflammatory response
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of isotype switching to IgG isotypes
positive regulation of regulatory T cell differentiation
positive regulation of tissue remodeling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tyrosine phosphorylation of Stat5 protein
protein kinase C-activating G-protein coupled receptor signaling pathway
Ras protein signal transduction
regulation of T cell homeostatic proliferation
response to ethanol
small GTPase mediated signal transduction
T cell differentiation
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- carbohydrate binding
cytokine activity
glycosphingolipid binding
growth factor activity
interleukin-2 receptor binding
kinase activator activity - Gene Ontology Cellular Component:
- cytosol
extracellular region
extracellular space - Keywords:
- 3D-structure
Adaptive immunity
Chromosomal rearrangement
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Immunity
Pharmaceutical
Proto-oncogene
Reference proteome
Secreted
Signal