Names & Taxonomy
- Uniprot ID:
- P60174
- Entry Name:
- TPIS_HUMAN
- Status:
- reviewed
- Protein Names:
- Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase)
- Gene Names:
- TPI1 TPI
- Gene Names Primary:
- TPI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 286
- Sequence:
- MAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
- Proteomes:
- UP000005640
Function
- Pathway:
- Carbohydrate biosynthesis; gluconeogenesis.; Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
- Catalytic Activity:
- D-glyceraldehyde 3-phosphate = glycerone phosphate.
- Active Site:
- ACT_SITE 133 133 Electrophile.; ACT_SITE 203 203 Proton acceptor.
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
nucleus
triose-phosphate isomerase activity
ubiquitin protein ligase binding
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
glyceraldehyde-3-phosphate biosynthetic process
glycerol catabolic process
glycolytic process
multicellular organism development
pentose-phosphate shunt
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
glyceraldehyde-3-phosphate biosynthetic process
glycerol catabolic process
glycolytic process
multicellular organism development
pentose-phosphate shunt
small molecule metabolic process - Gene Ontology Molecular Function:
- triose-phosphate isomerase activity
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Gluconeogenesis
Glycolysis
Hereditary hemolytic anemia
Isomerase
Nitration
Pentose shunt
Phosphoprotein
Polymorphism
Reference proteome - Interacts With:
- P12004; P54274
Publication
- PubMed ID:
- 2579079 4022011 8723724 9074930 14702039 16541075 2925688 15489334 6434534 9150946 9150948 17081983 16807684 17924679 17693683 19367720 18669648 19413330 19690332 19608861 20068231 21269460 21406692 22905912 24275569 25944712 8061610 16511037 18562316 2876430 1339398 8503454 8571957 9338582