Names & Taxonomy
- Uniprot ID:
- P59998
- Entry Name:
- ARPC4_HUMAN
- Status:
- reviewed
- Protein Names:
- Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC)
- Gene Names:
- ARPC4 ARC20
- Gene Names Primary:
- ARPC4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 168
- Sequence:
- MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSKELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFFILRRKPVEGYDISFLITNFHTEQMYKHKLVDFVIHFMEEIDKEISEMKLSVNARARIVAEEFLKNF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
- Gene Ontology Go:
- Arp2/3 protein complex
cell projection
cytosol
extracellular exosome
enzyme binding
structural constituent of cytoskeleton
actin filament polymerization
actin nucleation
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
small GTPase mediated signal transduction - Gene Ontology Biological Process:
- actin filament polymerization
actin nucleation
Arp2/3 complex-mediated actin nucleation
axon guidance
ephrin receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
small GTPase mediated signal transduction - Gene Ontology Molecular Function:
- enzyme binding
structural constituent of cytoskeleton - Gene Ontology Cellular Component:
- Arp2/3 protein complex
cell projection
cytosol
extracellular exosome - Keywords:
- Acetylation
Actin-binding
Alternative splicing
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Reference proteome - Interacts With:
- Q96PV4