Names & Taxonomy
- Uniprot ID:
- P58743
- Entry Name:
- S26A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Prestin (Solute carrier family 26 member 5)
- Gene Names:
- SLC26A5 PRES
- Gene Names Primary:
- SLC26A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 744
- Sequence:
- MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYAKEVGNANMANATVVKADAEVDGEDATKPEEEDGEVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
- Gene Ontology Go:
- basolateral plasma membrane
cytoplasm
integral component of plasma membrane
lateral plasma membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
bicarbonate transport
chloride transmembrane transport
cochlea development
fructose transport
negative regulation of ion transmembrane transport
oxalate transport
positive regulation of cell motility
positive regulation of cell size
protein tetramerization
regulation of cell shape
regulation of intracellular pH
regulation of membrane potential
response to auditory stimulus
response to drug
response to ischemia
response to potassium ion
response to salicylic acid
response to salt
response to thyroid hormone
sensory perception of sound
sulfate transmembrane transport - Gene Ontology Biological Process:
- bicarbonate transport
chloride transmembrane transport
cochlea development
fructose transport
negative regulation of ion transmembrane transport
oxalate transport
positive regulation of cell motility
positive regulation of cell size
protein tetramerization
regulation of cell shape
regulation of intracellular pH
regulation of membrane potential
response to auditory stimulus
response to drug
response to ischemia
response to potassium ion
response to salicylic acid
response to salt
response to thyroid hormone
sensory perception of sound
sulfate transmembrane transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cytoplasm
integral component of plasma membrane
lateral plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Cell shape
Complete proteome
Deafness
Glycoprotein
Hearing
Membrane
Motor protein
Non-syndromic deafness
Reference proteome
Transmembrane
Transmembrane helix