Names & Taxonomy

Uniprot ID:
P57103
Entry Name:
NAC3_HUMAN
Status:
reviewed
Protein Names:
Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
Gene Names:
SLC8A3 NCX3
Gene Names Primary:
SLC8A3
Organism:
Homo sapiens (Human)

Structure

Length:
927
Sequence:
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity).
Enzyme Regulation:
ENZYME REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).
Gene Ontology Go:
cell junction
dendritic spine
endoplasmic reticulum membrane
integral component of plasma membrane
intrinsic component of plasma membrane
microtubule
mitochondrial outer membrane
neuromuscular junction
perikaryon
perinuclear region of cytoplasm
plasma membrane
sarcolemma
sarcoplasm
calcium:sodium antiporter activity
metal ion binding
blood coagulation
calcium ion export from cell
calcium ion import into cell
calcium ion transmembrane transport
calcium ion transport into cytosol
cardiac conduction
cell communication
cellular calcium ion homeostasis
cellular response to cAMP
cellular response to hypoxia
hematopoietic progenitor cell differentiation
ion transport
learning
long-term synaptic potentiation
memory
mitochondrial calcium ion homeostasis
mitochondrial calcium ion transport
myelination
oligodendrocyte differentiation
regulation of cardiac conduction
regulation of skeletal muscle contraction
sodium ion transmembrane transport
telencephalon development
transmembrane transport
Gene Ontology Biological Process:
blood coagulation
calcium ion export from cell
calcium ion import into cell
calcium ion transmembrane transport
calcium ion transport into cytosol
cardiac conduction
cell communication
cellular calcium ion homeostasis
cellular response to cAMP
cellular response to hypoxia
hematopoietic progenitor cell differentiation
ion transport
learning
long-term synaptic potentiation
memory
mitochondrial calcium ion homeostasis
mitochondrial calcium ion transport
myelination
oligodendrocyte differentiation
regulation of cardiac conduction
regulation of skeletal muscle contraction
sodium ion transmembrane transport
telencephalon development
transmembrane transport
Gene Ontology Molecular Function:
calcium:sodium antiporter activity
metal ion binding
Gene Ontology Cellular Component:
cell junction
dendritic spine
endoplasmic reticulum membrane
integral component of plasma membrane
intrinsic component of plasma membrane
microtubule
mitochondrial outer membrane
neuromuscular junction
perikaryon
perinuclear region of cytoplasm
plasma membrane
sarcolemma
sarcoplasm
Keywords:
Alternative splicing
Antiport
Calcium
Calcium transport
Calmodulin-binding
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Endoplasmic reticulum
Glycoprotein
Ion transport
Membrane
Metal-binding
Mitochondrion
Mitochondrion outer membrane
Polymorphism
Reference proteome
Repeat
Signal
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12406570 12558991 15777725 12508121 15489334 21959935 23506867 16959974