Names & Taxonomy
- Uniprot ID:
- P56730
- Entry Name:
- NETR_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurotrypsin (EC 3.4.21.-) (Leydin) (Motopsin) (Serine protease 12)
- Gene Names:
- PRSS12
- Gene Names Primary:
- PRSS12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 875
- Sequence:
- MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
- Active Site:
- ACT_SITE 676 676 Charge relay system.
- Gene Ontology Go:
- axon
cytoplasmic vesicle
dendrite
plasma membrane
synaptic cleft
terminal bouton
scavenger receptor activity
serine-type endopeptidase activity
serine-type peptidase activity
exocytosis
zymogen activation - Gene Ontology Biological Process:
- exocytosis
zymogen activation - Gene Ontology Molecular Function:
- scavenger receptor activity
serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- axon
cytoplasmic vesicle
dendrite
plasma membrane
synaptic cleft
terminal bouton - Keywords:
- Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Kringle
Mental retardation
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal