Names & Taxonomy

Uniprot ID:
P56704
Entry Name:
WNT3A_HUMAN
Status:
reviewed
Protein Names:
Protein Wnt-3a
Gene Names:
WNT3A
Gene Names Primary:
WNT3A
Organism:
Homo sapiens (Human)

Structure

Length:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Function

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Gene Ontology Go:
cell surface
early endosome membrane
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
presynapse
proteinaceous extracellular matrix
Wnt-Frizzled-LRP5/6 complex
co-receptor binding
frizzled binding
receptor agonist activity
receptor binding
transcription coactivator activity
axis elongation involved in somitogenesis
axon guidance
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
cell proliferation in forebrain
cell proliferation in midbrain
cellular protein localization
cellular response to retinoic acid
COP9 signalosome assembly
dorsal/ventral neural tube patterning
extracellular matrix organization
heart looping
hemopoiesis
hippocampus development
in utero embryonic development
inner ear morphogenesis
mammary gland development
negative regulation of axon extension involved in axon guidance
negative regulation of canonical Wnt signaling pathway
negative regulation of dopaminergic neuron differentiation
negative regulation of fat cell differentiation
negative regulation of heart induction by canonical Wnt signaling pathway
negative regulation of neurogenesis
negative regulation of neuron projection development
neuron differentiation
osteoblast differentiation
palate development
paraxial mesodermal cell fate commitment
platelet aggregation
positive regulation of B cell proliferation
positive regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
positive regulation of cardiac muscle cell differentiation
positive regulation of catenin import into nucleus
positive regulation of cell proliferation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of collateral sprouting in absence of injury
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cytokine production
positive regulation of dermatome development
positive regulation of hepatocyte proliferation
positive regulation of mesodermal cell fate specification
positive regulation of neural precursor cell proliferation
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein binding
positive regulation of protein localization to plasma membrane
positive regulation of protein phosphorylation
positive regulation of protein tyrosine kinase activity
positive regulation of receptor internalization
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of skeletal muscle tissue development
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription regulatory region DNA binding
positive regulation of transcription, DNA-templated
post-anal tail morphogenesis
regulation of microtubule cytoskeleton organization
skeletal muscle cell differentiation
spinal cord association neuron differentiation
synapse assembly
synaptic vesicle recycling
Wnt signaling pathway involved in forebrain neuroblast division
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Gene Ontology Biological Process:
axis elongation involved in somitogenesis
axon guidance
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
cell proliferation in forebrain
cell proliferation in midbrain
cellular protein localization
cellular response to retinoic acid
COP9 signalosome assembly
dorsal/ventral neural tube patterning
extracellular matrix organization
heart looping
hemopoiesis
hippocampus development
inner ear morphogenesis
in utero embryonic development
mammary gland development
negative regulation of axon extension involved in axon guidance
negative regulation of canonical Wnt signaling pathway
negative regulation of dopaminergic neuron differentiation
negative regulation of fat cell differentiation
negative regulation of heart induction by canonical Wnt signaling pathway
negative regulation of neurogenesis
negative regulation of neuron projection development
neuron differentiation
osteoblast differentiation
palate development
paraxial mesodermal cell fate commitment
platelet aggregation
positive regulation of B cell proliferation
positive regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
positive regulation of cardiac muscle cell differentiation
positive regulation of catenin import into nucleus
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of cell proliferation
positive regulation of collateral sprouting in absence of injury
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cytokine production
positive regulation of dermatome development
positive regulation of hepatocyte proliferation
positive regulation of mesodermal cell fate specification
positive regulation of neural precursor cell proliferation
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein binding
positive regulation of protein localization to plasma membrane
positive regulation of protein phosphorylation
positive regulation of protein tyrosine kinase activity
positive regulation of receptor internalization
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of skeletal muscle tissue development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription regulatory region DNA binding
post-anal tail morphogenesis
regulation of microtubule cytoskeleton organization
skeletal muscle cell differentiation
spinal cord association neuron differentiation
synapse assembly
synaptic vesicle recycling
Wnt signaling pathway involved in forebrain neuroblast division
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Gene Ontology Molecular Function:
co-receptor binding
frizzled binding
receptor agonist activity
receptor binding
transcription coactivator activity
Gene Ontology Cellular Component:
cell surface
early endosome membrane
endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
presynapse
proteinaceous extracellular matrix
Wnt-Frizzled-LRP5/6 complex
Keywords:
Alternative splicing
Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal
Wnt signaling pathway
Interacts With:
Q9H461

Publication

PubMed ID:
11414706 14702039 16710414 15489334 8168088 16678095 20093360 20826466 20393562 21244856 24841207 24292069 25731175