Names & Taxonomy
- Uniprot ID:
- P56199
- Entry Name:
- ITA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)
- Gene Names:
- ITGA1
- Gene Names Primary:
- ITGA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1179
- Sequence:
- MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGKWVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGSNSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADLQYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFNLTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVPLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
- Gene Ontology Go:
- acrosomal vesicle
basal part of cell
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integrin alpha1-beta1 complex
integrin complex
membrane
membrane raft
neuron projection
perikaryon
plasma membrane
collagen binding
collagen binding involved in cell-matrix adhesion
metal ion binding
protein phosphatase binding
activation of MAPK activity
axon guidance
blood coagulation
cell-matrix adhesion
cellular extravasation
extracellular matrix organization
integrin-mediated signaling pathway
muscle contraction
negative regulation of cell proliferation
negative regulation of epidermal growth factor receptor signaling pathway
neutrophil chemotaxis
positive regulation of neuron apoptotic process
positive regulation of phosphoprotein phosphatase activity
vasodilation - Gene Ontology Biological Process:
- activation of MAPK activity
axon guidance
blood coagulation
cell-matrix adhesion
cellular extravasation
extracellular matrix organization
integrin-mediated signaling pathway
muscle contraction
negative regulation of cell proliferation
negative regulation of epidermal growth factor receptor signaling pathway
neutrophil chemotaxis
positive regulation of neuron apoptotic process
positive regulation of phosphoprotein phosphatase activity
vasodilation - Gene Ontology Molecular Function:
- collagen binding
collagen binding involved in cell-matrix adhesion
metal ion binding
protein phosphatase binding - Gene Ontology Cellular Component:
- acrosomal vesicle
basal part of cell
cell surface
external side of plasma membrane
extracellular exosome
focal adhesion
integrin alpha1-beta1 complex
integrin complex
membrane
membrane raft
neuron projection
perikaryon
plasma membrane - Keywords:
- 3D-structure
Calcium
Cell adhesion
Complete proteome
Disulfide bond
Glycoprotein
Integrin
Magnesium
Membrane
Metal-binding
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix