Names & Taxonomy

Uniprot ID:
P55290
Entry Name:
CAD13_HUMAN
Status:
reviewed
Protein Names:
Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)
Gene Names:
CDH13 CDHH
Gene Names Primary:
CDH13
Organism:
Homo sapiens (Human)

Structure

Length:
713
Sequence:
MQPRTPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVLLLSLFSLACL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Function

Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Gene Ontology Go:
anchored component of membrane
caveola
cytoplasm
external side of plasma membrane
extracellular exosome
extracellular space
focal adhesion
neuron projection
perinuclear region of cytoplasm
plasma membrane
adiponectin binding
cadherin binding
calcium ion binding
lipoprotein particle binding
low-density lipoprotein particle binding
adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell junction assembly
cell-cell junction organization
endothelial cell migration
homophilic cell adhesion via plasma membrane adhesion molecules
keratinocyte proliferation
lamellipodium assembly
localization within membrane
low-density lipoprotein particle mediated signaling
mitotic cell cycle
negative regulation of cell adhesion
negative regulation of cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of cell migration
positive regulation of cell-matrix adhesion
positive regulation of endothelial cell proliferation
positive regulation of positive chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
Rac protein signal transduction
regulation of endocytosis
regulation of epidermal growth factor receptor signaling pathway
Rho protein signal transduction
sprouting angiogenesis
Gene Ontology Biological Process:
adherens junction organization
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell junction organization
cell junction assembly
endothelial cell migration
homophilic cell adhesion via plasma membrane adhesion molecules
keratinocyte proliferation
lamellipodium assembly
localization within membrane
low-density lipoprotein particle mediated signaling
mitotic cell cycle
negative regulation of cell adhesion
negative regulation of cell proliferation
positive regulation of calcium-mediated signaling
positive regulation of cell-matrix adhesion
positive regulation of cell migration
positive regulation of endothelial cell proliferation
positive regulation of positive chemotaxis
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
Rac protein signal transduction
regulation of endocytosis
regulation of epidermal growth factor receptor signaling pathway
Rho protein signal transduction
sprouting angiogenesis
Gene Ontology Molecular Function:
adiponectin binding
cadherin binding
calcium ion binding
lipoprotein particle binding
low-density lipoprotein particle binding
Gene Ontology Cellular Component:
anchored component of membrane
caveola
cytoplasm
external side of plasma membrane
extracellular exosome
extracellular space
focal adhesion
neuron projection
perinuclear region of cytoplasm
plasma membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal

Publication

PubMed ID:
7982033 8673923 9737784 14702039 15616553 15489334 9468307 10737605 11027617 16335952 16602701 19159218 21220648