Names & Taxonomy
- Uniprot ID:
- P55210
- Entry Name:
- CASP7_HUMAN
- Status:
- reviewed
- Protein Names:
- Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
- Gene Names:
- CASP7 MCH3
- Gene Names Primary:
- CASP7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 303
- Sequence:
- MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
- Catalytic Activity:
- Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by isatin sulfonamides.
- Active Site:
- ACT_SITE 144 144
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
cysteine-type peptidase activity
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
execution phase of apoptosis
intrinsic apoptotic signaling pathway
programmed cell death
proteolysis - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
execution phase of apoptosis
intrinsic apoptotic signaling pathway
programmed cell death
proteolysis - Gene Ontology Molecular Function:
- cysteine-type endopeptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
cysteine-type peptidase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Hydrolase
Polymorphism
Protease
Reference proteome
Thiol protease
Zymogen - Interacts With:
- Q13490; Q13177; Q6ICU9; P17405; P98170