Names & Taxonomy
- Uniprot ID:
- P55157
- Entry Name:
- MTP_HUMAN
- Status:
- reviewed
- Protein Names:
- Microsomal triglyceride transfer protein large subunit
- Gene Names:
- MTTP MTP
- Gene Names Primary:
- MTTP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 894
- Sequence:
- MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).
- Cross Reference Drug Bank:
- DB01094 DB08827
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum lumen
receptor complex
lipid binding
lipid transporter activity
phospholipid transporter activity
protein heterodimerization activity
lipid metabolic process
lipoprotein metabolic process
phospholipid transport
plasma lipoprotein particle assembly
small molecule metabolic process
triglyceride transport - Gene Ontology Biological Process:
- lipid metabolic process
lipoprotein metabolic process
phospholipid transport
plasma lipoprotein particle assembly
small molecule metabolic process
triglyceride transport - Gene Ontology Molecular Function:
- lipid binding
lipid transporter activity
phospholipid transporter activity
protein heterodimerization activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum lumen
receptor complex - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Endoplasmic reticulum
Lipid-binding
Polymorphism
Reference proteome
Signal
Transport