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Names & Taxonomy

Uniprot ID:: P55072
Entry Name:: TERA_HUMAN
Status:: reviewed
Protein Names:: Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)
Gene Names:: VCP
Gene Names Primary:: VCP
Organism:: Homo sapiens (Human)

Structure

Length:: 806
Sequence:: MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSGNQGGAGPSQGSGGGTGGSVYTEDNDDDLYG
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN.

Function

Function:: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation.
Catalytic Activity:: ATP + H(2)O = ADP + phosphate.
Gene Ontology Go:: cytoplasm
cytosol
Derlin-1 retrotranslocation complex
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
lipid particle
myelin sheath
nucleoplasm
nucleus
perinuclear region of cytoplasm
proteasome complex
site of double-strand break
VCP-NPL4-UFD1 AAA ATPase complex
VCP-NSFL1C complex
ADP binding
ATP binding
ATPase activity
BAT3 complex binding
deubiquitinase activator activity
lipid binding
poly(A) RNA binding
polyubiquitin binding
protein domain specific binding
protein phosphatase binding
ubiquitin protein ligase binding
ubiquitin-like protein ligase binding
ubiquitin-specific protease binding
activation of cysteine-type endopeptidase activity involved in apoptotic process
aggresome assembly
ATP metabolic process
cellular response to DNA damage stimulus
cellular response to heat
DNA repair
double-strand break repair
endoplasmic reticulum unfolded protein response
ER to Golgi vesicle-mediated transport
ER-associated misfolded protein catabolic process
ER-associated ubiquitin-dependent protein catabolic process
ERAD pathway
error-free translesion synthesis
establishment of protein localization
flavin adenine dinucleotide catabolic process
NADH metabolic process
positive regulation of ATP biosynthetic process
positive regulation of Lys63-specific deubiquitinase activity
positive regulation of mitochondrial membrane potential
positive regulation of oxidative phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
positive regulation of protein complex assembly
positive regulation of protein K63-linked deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein hexamerization
protein homooligomerization
protein N-linked glycosylation via asparagine
protein ubiquitination
regulation of aerobic respiration
regulation of apoptotic process
retrograde protein transport, ER to cytosol
translesion synthesis
viral genome replication
Gene Ontology Biological Process:: activation of cysteine-type endopeptidase activity involved in apoptotic process
aggresome assembly
ATP metabolic process
cellular response to DNA damage stimulus
cellular response to heat
DNA repair
double-strand break repair
endoplasmic reticulum unfolded protein response
ERAD pathway
ER-associated misfolded protein catabolic process
ER-associated ubiquitin-dependent protein catabolic process
error-free translesion synthesis
ER to Golgi vesicle-mediated transport
establishment of protein localization
flavin adenine dinucleotide catabolic process
NADH metabolic process
positive regulation of ATP biosynthetic process
positive regulation of Lys63-specific deubiquitinase activity
positive regulation of mitochondrial membrane potential
positive regulation of oxidative phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
positive regulation of protein complex assembly
positive regulation of protein K63-linked deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein hexamerization
protein homooligomerization
protein N-linked glycosylation via asparagine
protein ubiquitination
regulation of aerobic respiration
regulation of apoptotic process
retrograde protein transport, ER to cytosol
translesion synthesis
viral genome replication
Gene Ontology Molecular Function:: ADP binding
ATPase activity
ATP binding
BAT3 complex binding
deubiquitinase activator activity
lipid binding
poly(A) RNA binding
polyubiquitin binding
protein domain specific binding
protein phosphatase binding
ubiquitin-like protein ligase binding
ubiquitin protein ligase binding
ubiquitin-specific protease binding
Gene Ontology Cellular Component:: cytoplasm
cytosol
Derlin-1 retrotranslocation complex
endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
intracellular membrane-bounded organelle
lipid particle
myelin sheath
nucleoplasm
nucleus
perinuclear region of cytoplasm
proteasome complex
site of double-strand break
VCP-NPL4-UFD1 AAA ATPase complex
VCP-NSFL1C complex
Keywords:: 3D-structure
ATP-binding
Acetylation
Amyotrophic lateral sclerosis
Complete proteome
Cytoplasm
DNA damage
DNA repair
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Hydrolase
Lipid-binding
Methylation
Neurodegeneration
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Transport
Ubl conjugation
Ubl conjugation pathway
Interacts With:: Q9UKV5; Q9BZE9; P54252; P54252-1; O96017; O94868; P62993; Q9UNZ2; P26045; B1AQ61; Q92575; Q9BZV1; P63104

Names & Taxonomy

Structure

Subcellular location

Function

Publication