Names & Taxonomy

Uniprot ID:
P54855
Entry Name:
UDB15_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
Gene Names:
UGT2B15 UGT2B8
Gene Names Primary:
UGT2B15
Organism:
Homo sapiens (Human)

Structure

Length:
530
Sequence:
MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome membrane

Function

Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB00316 DB06695 DB00973 DB00186 DB00295 DB00842 DB00313
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
glucuronosyltransferase activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
glucuronosyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
Keywords:
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
8399210 7835232 9295060 14702039 15815621 2116769 19159218 24275569 15618667