Names & Taxonomy
- Uniprot ID:
- P54855
- Entry Name:
- UDB15_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 2B15 (UDPGT 2B15) (EC 2.4.1.17) (HLUG4) (UDP-glucuronosyltransferase 2B8) (UDPGT 2B8) (UDPGTh-3)
- Gene Names:
- UGT2B15 UGT2B8
- Gene Names Primary:
- UGT2B15
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 530
- Sequence:
- MSLKWTSVFLLIQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATVIFIITKFCLFCFRKLAKKGKKKKRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane
Function
- Function:
- UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB00316 DB06695 DB00973 DB00186 DB00295 DB00842 DB00313
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
glucuronosyltransferase activity
cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular glucuronidation
flavonoid biosynthetic process
flavonoid glucuronidation
steroid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle - Keywords:
- Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix