Names & Taxonomy
- Uniprot ID:
- P54756
- Entry Name:
- EPHA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
- Gene Names:
- EPHA5 BSK EHK1 HEK7 TYRO4
- Gene Names Primary:
- EPHA5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1037
- Sequence:
- MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 800 800 Proton acceptor.
- Gene Ontology Go:
- axon
dendrite
external side of plasma membrane
integral component of plasma membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum
ATP binding
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
axon guidance
cAMP-mediated signaling
ephrin receptor signaling pathway
hippocampus development
neuron development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
regulation of insulin secretion involved in cellular response to glucose stimulus - Gene Ontology Biological Process:
- axon guidance
cAMP-mediated signaling
ephrin receptor signaling pathway
hippocampus development
neuron development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
regulation of insulin secretion involved in cellular response to glucose stimulus - Gene Ontology Molecular Function:
- ATP binding
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity - Gene Ontology Cellular Component:
- axon
dendrite
external side of plasma membrane
integral component of plasma membrane
neuronal cell body
perinuclear region of cytoplasm
plasma membrane
rough endoplasmic reticulum - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Complete proteome
Glycoprotein
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase