Names & Taxonomy
- Uniprot ID:
- P54368
- Entry Name:
- OAZ1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ornithine decarboxylase antizyme 1 (ODC-Az)
- Gene Names:
- OAZ1 OAZ
- Gene Names Primary:
- OAZ1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 228
- Sequence:
- MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE
- Proteomes:
- UP000005640
Function
- Function:
- Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
- Cross Reference Drug Bank:
- DB00129
- Gene Ontology Go:
- cytosol
ornithine decarboxylase inhibitor activity
cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process
transport - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process
transport - Gene Ontology Molecular Function:
- ornithine decarboxylase inhibitor activity
- Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Complete proteome
Polyamine biosynthesis
Polymorphism
Reference proteome
Ribosomal frameshifting
Transport