Names & Taxonomy
- Uniprot ID:
- P54317
- Entry Name:
- LIPR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase)
- Gene Names:
- PNLIPRP2 PLRP2
- Gene Names Primary:
- PNLIPRP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 469
- Sequence:
- MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGESGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKFLWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.
- Catalytic Activity:
- Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
- Enzyme Regulation:
- ENZYME REGULATION: CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.
- Active Site:
- ACT_SITE 171 171 Nucleophile.
- Gene Ontology Go:
- extracellular region
extracellular space
acylglycerol lipase activity
calcium ion binding
galactolipase activity
phospholipase activity
triglyceride lipase activity
galactolipid catabolic process
lipid digestion
phospholipid catabolic process
small molecule metabolic process
triglyceride metabolic process - Gene Ontology Biological Process:
- galactolipid catabolic process
lipid digestion
phospholipid catabolic process
small molecule metabolic process
triglyceride metabolic process - Gene Ontology Molecular Function:
- acylglycerol lipase activity
calcium ion binding
galactolipase activity
phospholipase activity
triglyceride lipase activity - Gene Ontology Cellular Component:
- extracellular region
extracellular space - Keywords:
- 3D-structure
Calcium
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Reference proteome
Secreted
Signal