Names & Taxonomy

Uniprot ID:
P54284
Entry Name:
CACB3_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)
Gene Names:
CACNB3 CACNLB3
Gene Names Primary:
CACNB3
Organism:
Homo sapiens (Human)

Structure

Length:
484
Sequence:
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY
Proteomes:
UP000005640

Function

Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Cross Reference Drug Bank:
DB04855 DB00393 DB00421 DB00661
Gene Ontology Go:
apical plasma membrane
cytosol
membrane
plasma membrane
voltage-gated calcium channel complex
high voltage-gated calcium channel activity
voltage-gated calcium channel activity
axon guidance
calcium ion transport
cardiac conduction
membrane depolarization
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
T cell receptor signaling pathway
transport
Gene Ontology Biological Process:
axon guidance
calcium ion transport
cardiac conduction
membrane depolarization
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
T cell receptor signaling pathway
transport
Gene Ontology Molecular Function:
high voltage-gated calcium channel activity
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
apical plasma membrane
cytosol
membrane
plasma membrane
voltage-gated calcium channel complex
Keywords:
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Ion channel
Ion transport
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Transport
Voltage-gated channel

Publication

PubMed ID:
7557998 8119293 14702039 16541075 15489334 12181424 19807924