Names & Taxonomy
- Uniprot ID:
- P54284
- Entry Name:
- CACB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3)
- Gene Names:
- CACNB3 CACNLB3
- Gene Names Primary:
- CACNB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 484
- Sequence:
- MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY
- Proteomes:
- UP000005640
Function
- Function:
- The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
- Cross Reference Drug Bank:
- DB04855 DB00393 DB00421 DB00661
- Gene Ontology Go:
- apical plasma membrane
cytosol
membrane
plasma membrane
voltage-gated calcium channel complex
high voltage-gated calcium channel activity
voltage-gated calcium channel activity
axon guidance
calcium ion transport
cardiac conduction
membrane depolarization
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
T cell receptor signaling pathway
transport - Gene Ontology Biological Process:
- axon guidance
calcium ion transport
cardiac conduction
membrane depolarization
neuromuscular junction development
regulation of voltage-gated calcium channel activity
synaptic transmission
T cell receptor signaling pathway
transport - Gene Ontology Molecular Function:
- high voltage-gated calcium channel activity
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
cytosol
membrane
plasma membrane
voltage-gated calcium channel complex - Keywords:
- Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Ion channel
Ion transport
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
Transport
Voltage-gated channel