Names & Taxonomy
- Uniprot ID:
- P54219
- Entry Name:
- VMAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
- Gene Names:
- SLC18A1 VAT1 VMAT1
- Gene Names Primary:
- SLC18A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 525
- Sequence:
- MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLSTVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasmic vesicle membrane
Function
- Function:
- Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
- Cross Reference Drug Bank:
- DB01363 DB01577 DB00368 DB00206
- Gene Ontology Go:
- clathrin-sculpted monoamine transport vesicle membrane
endoplasmic reticulum membrane
integral component of membrane
presynapse
drug transmembrane transporter activity
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity
cellular response to lithium ion
monoamine transport
negative regulation of serotonin uptake
positive regulation of dopamine secretion
serotonin uptake
transmembrane transport - Gene Ontology Biological Process:
- cellular response to lithium ion
monoamine transport
negative regulation of serotonin uptake
positive regulation of dopamine secretion
serotonin uptake
transmembrane transport - Gene Ontology Molecular Function:
- drug transmembrane transporter activity
monoamine transmembrane transporter activity
serotonin transmembrane transporter activity - Gene Ontology Cellular Component:
- clathrin-sculpted monoamine transport vesicle membrane
endoplasmic reticulum membrane
integral component of membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Glycoprotein
Membrane
Neurotransmitter transport
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport