Names & Taxonomy
- Uniprot ID:
- P53985
- Entry Name:
- MOT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)
- Gene Names:
- SLC16A1 MCT1
- Gene Names Primary:
- SLC16A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 500
- Sequence:
- MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
- Cross Reference Drug Bank:
- DB03166 DB00345 DB00415 DB03793 DB00529 DB01440 DB04398 DB00563 DB00731 DB00627 DB04552 DB00175 DB01032 DB00119 DB00936 DB00313
- Gene Ontology Go:
- centrosome
extracellular exosome
integral component of membrane
integral component of plasma membrane
membrane
mitochondrion
plasma membrane
lactate transmembrane transporter activity
mevalonate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
organic cyclic compound binding
symporter activity
behavioral response to nutrient
blood coagulation
cellular metabolic process
cellular response to organic cyclic compound
centrosome organization
glucose homeostasis
leukocyte migration
lipid metabolic process
mevalonate transport
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
regulation of insulin secretion
response to food
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- behavioral response to nutrient
blood coagulation
cellular metabolic process
cellular response to organic cyclic compound
centrosome organization
glucose homeostasis
leukocyte migration
lipid metabolic process
mevalonate transport
monocarboxylic acid transport
plasma membrane lactate transport
pyruvate metabolic process
regulation of insulin secretion
response to food
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- lactate transmembrane transporter activity
mevalonate transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
organic cyclic compound binding
symporter activity - Gene Ontology Cellular Component:
- centrosome
extracellular exosome
integral component of membrane
integral component of plasma membrane
membrane
mitochondrion
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport