Names & Taxonomy

Uniprot ID:
P53675
Entry Name:
CLH2_HUMAN
Status:
reviewed
Protein Names:
Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)
Gene Names:
CLTCL1 CLH22 CLTCL CLTD
Gene Names Primary:
CLTCL1
Organism:
Homo sapiens (Human)

Structure

Length:
1640
Sequence:
MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPAPLVFDFDGHE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle membrane

Function

Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
Gene Ontology Go:
clathrin coat of trans-Golgi network vesicle
clathrin-coated vesicle
coated pit
coated vesicle
extracellular exosome
late endosome
membrane
sorting endosome
spindle
trans-Golgi network
signal transducer activity
structural molecule activity
anatomical structure morphogenesis
intracellular protein transport
mitotic nuclear division
positive regulation of glucose import
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
signal transduction
Gene Ontology Biological Process:
anatomical structure morphogenesis
intracellular protein transport
mitotic nuclear division
positive regulation of glucose import
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
signal transduction
Gene Ontology Molecular Function:
signal transducer activity
structural molecule activity
Gene Ontology Cellular Component:
clathrin-coated vesicle
clathrin coat of trans-Golgi network vesicle
coated pit
coated vesicle
extracellular exosome
late endosome
membrane
sorting endosome
spindle
trans-Golgi network
Keywords:
Acetylation
Alternative splicing
Coated pit
Complete proteome
Cytoplasmic vesicle
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat

Publication

PubMed ID:
8733128 8733129 8844170 14702039 20068231