Names & Taxonomy
- Uniprot ID:
- P53611
- Entry Name:
- PGTB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)
- Gene Names:
- RABGGTB GGTB
- Gene Names Primary:
- RABGGTB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 331
- Sequence:
- MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
- Catalytic Activity:
- Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Enzyme Regulation:
- ENZYME REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A).
- Gene Ontology Go:
- Rab-protein geranylgeranyltransferase complex
Rab geranylgeranyltransferase activity
Rab GTPase binding
zinc ion binding
cellular protein modification process
protein geranylgeranylation
visual perception - Gene Ontology Biological Process:
- cellular protein modification process
protein geranylgeranylation
visual perception - Gene Ontology Molecular Function:
- Rab geranylgeranyltransferase activity
Rab GTPase binding
zinc ion binding - Gene Ontology Cellular Component:
- Rab-protein geranylgeranyltransferase complex
- Keywords:
- Acetylation
Complete proteome
Metal-binding
Phosphoprotein
Prenyltransferase
Reference proteome
Repeat
Transferase
Zinc - Interacts With:
- P10398; Q9UBV7; Q7Z5A9; Q86YD3; P57081