Names & Taxonomy
- Uniprot ID:
- P53597
- Entry Name:
- SUCA_HUMAN
- Status:
- reviewed
- Protein Names:
- Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
- Gene Names:
- SUCLG1
- Gene Names Primary:
- SUCLG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 346
- Sequence:
- MTATLAAAADIATMVSGSSGLAAARLLSRSFLLPQNGIRHCSYTASRQHLYVDKNTKIICQGFTGKQGTFHSQQALEYGTKLVGGTTPGKGGQTHLGLPVFNTVKEAKEQTGATASVIYVPPPFAAAAINEAIEAEIPLVVCITEGIPQQDMVRVKHKLLRQEKTRLIGPNCPGVINPGECKIGIMPGHIHKKGRIGIVSRSGTLTYEAVHQTTQVGLGQSLCVGIGGDPFNGTDFIDCLEIFLNDSATEGIILIGEIGGNAEENAAEFLKQHNSGPNSKPVVSFIAGLTAPPGRRMGHAGAIIAGGKGGAKEKISALQSAGVVVSMSPAQLGTTIYKEFEKRKML
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity).
- Pathway:
- Carbohydrate metabolism; tricarboxylic acid cycle.
- Catalytic Activity:
- GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.; ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
- Active Site:
- ACT_SITE 299 299 Tele-phosphohistidine intermediate.
- Cross Reference Drug Bank:
- DB00139
- Gene Ontology Go:
- cytoplasm
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
plasma membrane
cofactor binding
GTP binding
poly(A) RNA binding
succinate-CoA ligase (ADP-forming) activity
succinate-CoA ligase (GDP-forming) activity
cellular metabolic process
nucleoside triphosphate biosynthetic process
small molecule metabolic process
succinate metabolic process
succinyl-CoA metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- cellular metabolic process
nucleoside triphosphate biosynthetic process
small molecule metabolic process
succinate metabolic process
succinyl-CoA metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- cofactor binding
GTP binding
poly(A) RNA binding
succinate-CoA ligase (ADP-forming) activity
succinate-CoA ligase (GDP-forming) activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
plasma membrane - Keywords:
- Acetylation
Complete proteome
Disease mutation
GTP-binding
Isopeptide bond
Ligase
Mitochondrion
Nucleotide-binding
Reference proteome
Transit peptide
Tricarboxylic acid cycle
Ubl conjugation