Names & Taxonomy
- Uniprot ID:
- P53396
- Entry Name:
- ACLY_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
- Gene Names:
- ACLY
- Gene Names Primary:
- ACLY
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1101
- Sequence:
- MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
- Catalytic Activity:
- ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
- Active Site:
- ACT_SITE 760 760 Tele-phosphohistidine intermediate.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
nucleoplasm
plasma membrane
ATP binding
ATP citrate synthase activity
cofactor binding
metal ion binding
acetyl-CoA biosynthetic process
cellular lipid metabolic process
cholesterol biosynthetic process
citrate metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
lipid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
oxaloacetate metabolic process
positive regulation of cellular metabolic process
small molecule metabolic process
triglyceride biosynthetic process - Gene Ontology Biological Process:
- acetyl-CoA biosynthetic process
cellular lipid metabolic process
cholesterol biosynthetic process
citrate metabolic process
energy reserve metabolic process
fatty acid biosynthetic process
lipid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
oxaloacetate metabolic process
positive regulation of cellular metabolic process
small molecule metabolic process
triglyceride biosynthetic process - Gene Ontology Molecular Function:
- ATP binding
ATP citrate synthase activity
cofactor binding
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Ubl conjugation