Names & Taxonomy
- Uniprot ID:
- P52789
- Entry Name:
- HXK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase)
- Gene Names:
- HK2
- Gene Names Primary:
- HK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 917
- Sequence:
- MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion outer membrane
Function
- Pathway:
- Carbohydrate metabolism; hexose metabolism.
- Catalytic Activity:
- ATP + D-hexose = ADP + D-hexose 6-phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.
- Gene Ontology Go:
- cytosol
membrane
mitochondrial outer membrane
ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity
apoptotic mitochondrial changes
canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose 6-phosphate metabolic process
glucose metabolic process
glucose transport
glycolytic process
hexose transport
lactation
maintenance of protein location in mitochondrion
mitophagy in response to mitochondrial depolarization
negative regulation of mitochondrial membrane permeability
negative regulation of reactive oxygen species metabolic process
regulation of glucose import
response to ischemia
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
canonical glycolysis
carbohydrate metabolic process
cellular glucose homeostasis
establishment of protein localization to mitochondrion
glucose 6-phosphate metabolic process
glucose metabolic process
glucose transport
glycolytic process
hexose transport
lactation
maintenance of protein location in mitochondrion
mitophagy in response to mitochondrial depolarization
negative regulation of mitochondrial membrane permeability
negative regulation of reactive oxygen species metabolic process
regulation of glucose import
response to ischemia
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
fructokinase activity
glucokinase activity
glucose binding
hexokinase activity
mannokinase activity - Gene Ontology Cellular Component:
- cytosol
membrane
mitochondrial outer membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Allosteric enzyme
Complete proteome
Glycolysis
Kinase
Membrane
Mitochondrion
Mitochondrion outer membrane
Nucleotide-binding
Polymorphism
Reference proteome
Repeat
Transferase - Interacts With:
- Q6FHH8; Q9UMX0; Q9UMX0-2