Names & Taxonomy
- Uniprot ID:
- P52788
- Entry Name:
- SPSY_HUMAN
- Status:
- reviewed
- Protein Names:
- Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)
- Gene Names:
- SMS
- Gene Names Primary:
- SMS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 366
- Sequence:
- MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFANLRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAIDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAKP
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
- Pathway:
- Amine and polyamine biosynthesis; spermine biosynthesis; spermine from spermidine: step 1/1.
- Catalytic Activity:
- S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine.
- Active Site:
- ACT_SITE 276 276 Proton acceptor.
- Cross Reference Drug Bank:
- DB00127
- Gene Ontology Go:
- cytosol
extracellular exosome
spermine synthase activity
cellular nitrogen compound metabolic process
methionine metabolic process
polyamine metabolic process
small molecule metabolic process
spermine biosynthetic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
methionine metabolic process
polyamine metabolic process
small molecule metabolic process
spermine biosynthetic process - Gene Ontology Molecular Function:
- spermine synthase activity
- Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Mental retardation
Polyamine biosynthesis
Polymorphism
Reference proteome
Transferase