Names & Taxonomy

Uniprot ID:
P52758
Entry Name:
UK114_HUMAN
Status:
reviewed
Protein Names:
Ribonuclease UK114 (EC 3.1.-.-) (14.5 kDa translational inhibitor protein) (p14.5) (Heat-responsive protein 12) (UK114 antigen homolog)
Gene Names:
HRSP12 PSP
Gene Names Primary:
HRSP12
Organism:
Homo sapiens (Human)

Structure

Length:
137
Sequence:
MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.

Function

Function:
Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).
Cross Reference Drug Bank:
DB03793
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
peroxisome
endoribonuclease activity, producing 3'-phosphomonoesters
long-chain fatty acid binding
platinum binding
poly(A) RNA binding
transition metal ion binding
xenon atom binding
brain development
G1 to G0 transition
kidney development
lung development
negative regulation of epithelial cell proliferation
negative regulation of translation
regulation of translational termination
response to lipid
response to salt
Gene Ontology Biological Process:
brain development
G1 to G0 transition
kidney development
lung development
negative regulation of epithelial cell proliferation
negative regulation of translation
regulation of translational termination
response to lipid
response to salt
Gene Ontology Molecular Function:
endoribonuclease activity, producing 3'-phosphomonoesters
long-chain fatty acid binding
platinum binding
poly(A) RNA binding
transition metal ion binding
xenon atom binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
peroxisome
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Endonuclease
Hydrolase
Nuclease
Nucleus
Phosphoprotein
Reference proteome

Publication

PubMed ID:
8973653 15489334 21269460 24275569 25944712 14997576