Names & Taxonomy
- Uniprot ID:
- P52569
- Entry Name:
- CTR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
- Gene Names:
- SLC7A2 ATRC2 CAT2
- Gene Names Primary:
- SLC7A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 658
- Sequence:
- MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
- Cross Reference Drug Bank:
- DB00123 DB00129
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
antiporter activity
basic amino acid transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
high-affinity L-ornithine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity
L-amino acid transmembrane transporter activity
low-affinity L-arginine transmembrane transporter activity
amino acid transport
basic amino acid transmembrane transport
cellular amino acid metabolic process
ion transport
L-arginine import across plasma membrane
L-lysine import across plasma membrane
L-ornithine import across plasma membrane
macrophage activation
nitric oxide biosynthetic process
nitric oxide production involved in inflammatory response
regulation of inflammatory response
regulation of macrophage activation
transmembrane transport
transport - Gene Ontology Biological Process:
- amino acid transport
basic amino acid transmembrane transport
cellular amino acid metabolic process
ion transport
L-arginine import across plasma membrane
L-lysine import across plasma membrane
L-ornithine import across plasma membrane
macrophage activation
nitric oxide biosynthetic process
nitric oxide production involved in inflammatory response
regulation of inflammatory response
regulation of macrophage activation
transmembrane transport
transport - Gene Ontology Molecular Function:
- antiporter activity
basic amino acid transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
high-affinity L-ornithine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity
L-amino acid transmembrane transporter activity
low-affinity L-arginine transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport