Names & Taxonomy

Uniprot ID:
P52569
Entry Name:
CTR2_HUMAN
Status:
reviewed
Protein Names:
Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
Gene Names:
SLC7A2 ATRC2 CAT2
Gene Names Primary:
SLC7A2
Organism:
Homo sapiens (Human)

Structure

Length:
658
Sequence:
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
Cross Reference Drug Bank:
DB00123 DB00129
Gene Ontology Go:
integral component of plasma membrane
membrane
plasma membrane
antiporter activity
basic amino acid transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
high-affinity L-ornithine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity
L-amino acid transmembrane transporter activity
low-affinity L-arginine transmembrane transporter activity
amino acid transport
basic amino acid transmembrane transport
cellular amino acid metabolic process
ion transport
L-arginine import across plasma membrane
L-lysine import across plasma membrane
L-ornithine import across plasma membrane
macrophage activation
nitric oxide biosynthetic process
nitric oxide production involved in inflammatory response
regulation of inflammatory response
regulation of macrophage activation
transmembrane transport
transport
Gene Ontology Biological Process:
amino acid transport
basic amino acid transmembrane transport
cellular amino acid metabolic process
ion transport
L-arginine import across plasma membrane
L-lysine import across plasma membrane
L-ornithine import across plasma membrane
macrophage activation
nitric oxide biosynthetic process
nitric oxide production involved in inflammatory response
regulation of inflammatory response
regulation of macrophage activation
transmembrane transport
transport
Gene Ontology Molecular Function:
antiporter activity
basic amino acid transmembrane transporter activity
high-affinity arginine transmembrane transporter activity
high-affinity L-ornithine transmembrane transporter activity
high-affinity lysine transmembrane transporter activity
L-amino acid transmembrane transporter activity
low-affinity L-arginine transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of plasma membrane
membrane
plasma membrane
Keywords:
Alternative splicing
Amino-acid transport
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8954799 9174363 16421571 15489334 17974005 18669648 20068231 24275569