Names & Taxonomy
- Uniprot ID:
- P52272
- Entry Name:
- HNRPM_HUMAN
- Status:
- reviewed
- Protein Names:
- Heterogeneous nuclear ribonucleoprotein M (hnRNP M)
- Gene Names:
- HNRNPM HNRPM NAGR1
- Gene Names Primary:
- HNRNPM
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 730
- Sequence:
- MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
- Gene Ontology Go:
- catalytic step 2 spliceosome
cell surface
extracellular exosome
extracellular matrix
integral component of plasma membrane
membrane
nuclear matrix
nucleolus
nucleoplasm
paraspeckles
spliceosomal complex
nucleotide binding
poly(A) RNA binding
protein domain specific binding
RNA binding
alternative mRNA splicing, via spliceosome
cellular response to carcinoembryonic antigen
cellular response to lipopolysaccharide
gene expression
mRNA splicing, via spliceosome
positive regulation of protein import
positive regulation of protein localization to nucleus
RNA splicing - Gene Ontology Biological Process:
- alternative mRNA splicing, via spliceosome
cellular response to carcinoembryonic antigen
cellular response to lipopolysaccharide
gene expression
mRNA splicing, via spliceosome
positive regulation of protein import
positive regulation of protein localization to nucleus
RNA splicing - Gene Ontology Molecular Function:
- nucleotide binding
poly(A) RNA binding
protein domain specific binding
RNA binding - Gene Ontology Cellular Component:
- catalytic step 2 spliceosome
cell surface
extracellular exosome
extracellular matrix
integral component of plasma membrane
membrane
nuclear matrix
nucleolus
nucleoplasm
paraspeckles
spliceosomal complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Ribonucleoprotein
Spliceosome
Ubl conjugation
mRNA processing
mRNA splicing - Interacts With:
- Q99996-2; Q99459; Q8AZK7; Q8NEA9; P52597; P25791; O43660; Q8WW24