Names & Taxonomy

Uniprot ID:
P52272
Entry Name:
HNRPM_HUMAN
Status:
reviewed
Protein Names:
Heterogeneous nuclear ribonucleoprotein M (hnRNP M)
Gene Names:
HNRNPM HNRPM NAGR1
Gene Names Primary:
HNRNPM
Organism:
Homo sapiens (Human)

Structure

Length:
730
Sequence:
MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPAQNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus, nucleolus

Function

Function:
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Gene Ontology Go:
catalytic step 2 spliceosome
cell surface
extracellular exosome
extracellular matrix
integral component of plasma membrane
membrane
nuclear matrix
nucleolus
nucleoplasm
paraspeckles
spliceosomal complex
nucleotide binding
poly(A) RNA binding
protein domain specific binding
RNA binding
alternative mRNA splicing, via spliceosome
cellular response to carcinoembryonic antigen
cellular response to lipopolysaccharide
gene expression
mRNA splicing, via spliceosome
positive regulation of protein import
positive regulation of protein localization to nucleus
RNA splicing
Gene Ontology Biological Process:
alternative mRNA splicing, via spliceosome
cellular response to carcinoembryonic antigen
cellular response to lipopolysaccharide
gene expression
mRNA splicing, via spliceosome
positive regulation of protein import
positive regulation of protein localization to nucleus
RNA splicing
Gene Ontology Molecular Function:
nucleotide binding
poly(A) RNA binding
protein domain specific binding
RNA binding
Gene Ontology Cellular Component:
catalytic step 2 spliceosome
cell surface
extracellular exosome
extracellular matrix
integral component of plasma membrane
membrane
nuclear matrix
nucleolus
nucleoplasm
paraspeckles
spliceosomal complex
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Ribonucleoprotein
Spliceosome
Ubl conjugation
mRNA processing
mRNA splicing
Interacts With:
Q99996-2; Q99459; Q8AZK7; Q8NEA9; P52597; P25791; O43660; Q8WW24

Publication

PubMed ID:
8441656 8692693 15489334 11991638 15561718 17081983 18691976 18669648 19413330 19690332 19608861 20068231 21269460 21406692 22223895 24275569 25218447 25772364 25755297 25944712