Names & Taxonomy

Uniprot ID:
P51841
Entry Name:
GUC2F_HUMAN
Status:
reviewed
Protein Names:
Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2)
Gene Names:
GUCY2F GUC2F RETGC2
Gene Names Primary:
GUCY2F
Organism:
Homo sapiens (Human)

Structure

Length:
1108
Sequence:
MFLGLGRFSRLVLWFAAFRKLLGHHGLASAKFLWCLCLLSVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEYVILNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELDNKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVGVVLTTGQDSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVESQEKTFYQAFTEAAARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLVQHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFPGGRPPRADAKCWFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRKAERQLVRNKP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Catalytic Activity:
GTP = 3',5'-cyclic GMP + diphosphate.
Enzyme Regulation:
ENZYME REGULATION: Activated by GCAP-1; inhibited by calcium.
Gene Ontology Go:
guanylate cyclase complex, soluble
integral component of plasma membrane
nuclear outer membrane
photoreceptor disc membrane
ATP binding
GTP binding
guanylate cyclase activity
protein kinase activity
receptor activity
detection of light stimulus involved in visual perception
intracellular signal transduction
phototransduction, visible light
receptor guanylyl cyclase signaling pathway
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
visual perception
Gene Ontology Biological Process:
detection of light stimulus involved in visual perception
intracellular signal transduction
phototransduction, visible light
receptor guanylyl cyclase signaling pathway
regulation of rhodopsin mediated signaling pathway
rhodopsin mediated signaling pathway
visual perception
Gene Ontology Molecular Function:
ATP binding
GTP binding
guanylate cyclase activity
protein kinase activity
receptor activity
Gene Ontology Cellular Component:
guanylate cyclase complex, soluble
integral component of plasma membrane
nuclear outer membrane
photoreceptor disc membrane
Keywords:
Complete proteome
Disulfide bond
GTP-binding
Lyase
Membrane
Nucleotide-binding
Polymorphism
Reference proteome
Sensory transduction
Signal
Transmembrane
Transmembrane helix
Vision
cGMP biosynthesis

Publication

PubMed ID:
7777544 15772651 16959974 17344846 23033978