Names & Taxonomy
- Uniprot ID:
- P51828
- Entry Name:
- ADCY7_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7)
- Gene Names:
- ADCY7 KIAA0037
- Gene Names Primary:
- ADCY7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1080
- Sequence:
- MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
- Catalytic Activity:
- ATP = 3',5'-cyclic AMP + diphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Gene Ontology Go:
- integral component of membrane
intracellular
plasma membrane
adenylate cyclase activity
ATP binding
metal ion binding
activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP-mediated signaling
cellular response to ethanol
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
maternal process involved in female pregnancy
neurotrophin TRK receptor signaling pathway
positive regulation of cAMP biosynthetic process
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport - Gene Ontology Biological Process:
- activation of phospholipase C activity
activation of protein kinase A activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
cAMP-mediated signaling
cellular response to ethanol
cellular response to glucagon stimulus
energy reserve metabolic process
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
maternal process involved in female pregnancy
neurotrophin TRK receptor signaling pathway
positive regulation of cAMP biosynthetic process
renal water homeostasis
signal transduction
small molecule metabolic process
synaptic transmission
transmembrane transport
water transport - Gene Ontology Molecular Function:
- adenylate cyclase activity
ATP binding
metal ion binding - Gene Ontology Cellular Component:
- integral component of membrane
intracellular
plasma membrane - Keywords:
- ATP-binding
Complete proteome
Glycoprotein
Lyase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Reference proteome
Repeat
Transmembrane
Transmembrane helix
cAMP biosynthesis