Names & Taxonomy
- Uniprot ID:
- P51798
- Entry Name:
- CLCN7_HUMAN
- Status:
- reviewed
- Protein Names:
- H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)
- Gene Names:
- CLCN7
- Gene Names Primary:
- CLCN7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 805
- Sequence:
- MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
- Intramembrane:
- INTRAMEM 206 213 Helical.
Function
- Function:
- Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
- Gene Ontology Go:
- cytoplasmic vesicle
integral component of membrane
lysosomal membrane
membrane
antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity
chloride transmembrane transport
ion transmembrane transport
response to pH
transmembrane transport
transport - Gene Ontology Biological Process:
- chloride transmembrane transport
ion transmembrane transport
response to pH
transmembrane transport
transport - Gene Ontology Molecular Function:
- antiporter activity
ATP binding
chloride channel activity
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- cytoplasmic vesicle
integral component of membrane
lysosomal membrane
membrane - Keywords:
- ATP-binding
Alternative splicing
Antiport
CBS domain
Chloride
Complete proteome
Disease mutation
Ion transport
Lysosome
Membrane
Nucleotide-binding
Osteopetrosis
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport